, Volume 32, Issue 5, pp 604-606

Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C 9333-Go/CGP 4540)

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Summary

A procedure to enhance the schistosomicidal effectiveness in vivo of an isothiocyanate derivative and some of its antischistosomal properties are reported. Determinations of the effects of this compound on tissue thiol levels and on highly sensitive bacterial tester strains have indicated that its mutagenic potential is of a low order and that the latter is decreased further after reduction of the host's intestinal bacterial flora.

Acknowledgments. Supported, in part, by grants No. AI-08022 and No. GM-16492 from the National Institutes of Health, and No. 274-0063 (JHU No. 1) from The Edna McConnell Clark Foundation. We wish to express our sincere appreciation to Dr.H. Striebel and Dr.F. Kradolfer of Ciba-Geigy for providing us with the isothiocyanate derivative and with information about its biological activities, and to Dr.H. van der Schalie and to Dr.H. Blankespoor of the Museum of Zoology, University of Michigan, for supplying us with mice infected with 3 strains ofS. japonicum (under contract No. N01-AI-42504, NIH).