Effect of subinhibitory concentrations of cefamandole and cefuroxime on adherence ofStaphylococcus aureus andStaphylococcus epidermidis to polystyrene culture plates

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Abstract

The ability of cefamandole and cefuroxime to inhibit adherence of staphylococci to polystyrene culture plates was tested in an in vitro assay using eight strains each ofStaphylococcus aureus andStaphylococcus epidermidis. The results indicated that subinhibitory concentrations of cefamandole and cefuroxime altered the adherence ability of both staphylococcal species, inhibition of adherence being more marked in the presence of cefamandole. It may be important to consider antiadherence properties in association with bactericidal activity when selecting agents for antibiotic prophylaxis.