Experientia

, Volume 37, Issue 11, pp 1141–1142

Pseudocholinesterase in obesity: Hypercaloric diet induced changes in experimental obese mice

  • K. M. Kutty
  • S. N. Huang
  • K. T. Kean
Article

DOI: 10.1007/BF01989883

Cite this article as:
Kutty, K.M., Huang, S.N. & Kean, K.T. Experientia (1981) 37: 1141. doi:10.1007/BF01989883
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Summary

Pseudocholinesterase activity is significantly higher in liver and serum, but lower in adipose tissue of genetically obese, diabetic and gold thioglucose treated mice. Similar enzyme changes were also observed in lean mice on a high carbohydrate diet. A marked reduction (40%) in PChE activity occurred in the liver of genetically diabetic mice when starved for 24 h. These observations suggest that pseudocholinesterase induction in the liver and repression in the adipose tissue is affected by excessive calorie intake in obesity. This provides a model to study the biological function of PChE in health and disease.

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • K. M. Kutty
    • 1
  • S. N. Huang
    • 1
  • K. T. Kean
    • 1
  1. 1.Department of Laboratory Medicine, The Dr Charles A. Janeway Child Health Centre and Discipline of PathologyMemorial University of NewfoundlandSt. John'sCanada

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