Agents and Actions

, Volume 34, Issue 3, pp 316–323

Circulatory depression and ventricular arrhythmias induced by compound 48/80 in anaesthetized rats

Allergy, Histamine and Kinins

DOI: 10.1007/BF01988722

Cite this article as:
Dai, S. Agents and Actions (1991) 34: 316. doi:10.1007/BF01988722

Abstract

The effects of graded doses of compound 48/80 on various cardiovascular and respiratory parameters were studied in pentobarbitone-anaesthetized rats. Following intravenous injections, this compound significantly depressed the mean blood pressure (MBP), left ventricular pressure (LVP) and dLVP/dtmax, and caused ventricular tachycardia (VT) or fibrillation (VF) and death. Heart rate (HR) response were variable, and there were no marked changes in airway resistance or blood gases. Pretreatment of the animals with either cimetidine or diphenhydramine significantly prolonged the time of onset of VT/VF but failed to alter the changes in other circulatory variables. A combination of cimetidine and diphenhydramine significantly alleviated the decreases in MBP and LVP and prevented the occurrence of VT/VF. It is suggested that the circulatory depression and the occurrence of ventricular arrhythmias following the administration of compound 48/80 result from activation of H1- and H2-receptors by elevated blood histamine levels due to release of the amine from tissues.

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • S. Dai
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of Hong KongHong Kong
  2. 2.Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouverCanada

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