Papers Presented at the Joint Meeting of the European Inflammation Society and Hungarian Biochemical Society Balatonaliga, Hungary, 19–21 May, 1993

Agents and Actions

, Volume 41, Issue 1, pp 108-110

First online:

Lewis antigen expression on human monocytes and binding of pyrogenic toxins

  • S. D. EsseryAffiliated withDepartment of Medical Microbiology The Medical School, University of Edinburgh
  • , A. T. SaadiAffiliated withDepartment of Medical Microbiology The Medical School, University of Edinburgh
  • , S. J. TwiteAffiliated withDepartment of Medical Microbiology The Medical School, University of Edinburgh
  • , D. M. WeirAffiliated withDepartment of Medical Microbiology The Medical School, University of Edinburgh
  • , C. C. BlackwellAffiliated withDepartment of Medical Microbiology The Medical School, University of Edinburgh
  • , A. BusuttilAffiliated withForensic Medicine Unit, The Medical School, University of Edinburgh

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Abstract

Toxigenic bacteria such asBordetella pertussis andStaphylococcus aureus have been implicated in some cases of sudden infant death syndrome (SIDS). We have previously demonstrated that the Lewisa antigen is an epithelial cell receptor forS. aureus, and this study demonstrated that Lewisa on human monocytes is also a receptor for staphylococcal enterotoxin B (SEB). Values obtained in assays for production of TNF-alpha and nitric oxide were greater for monocytes treated with SEB compared with those treated with lipopolysaccharide (LPS). Exposure to LPS increased the expression of Lewisa on monocytes. These results are discussed with reference to the reported enhancement of endotoxic shock by pyrogenic toxins.

Key words

Sudden infant death syndrome Staphylococcal enterotoxins LPS Nitric oxide TNF-α Lewis antigens Monocytes