, Volume 50, Issue 2, pp 87–93

Shear-dependence of endothelial functions

  • W. H. Reinhart

DOI: 10.1007/BF01984940

Cite this article as:
Reinhart, W.H. Experientia (1994) 50: 87. doi:10.1007/BF01984940


Endothelial cells are subjected to shear forces which influence important cell functions. Shear stress induces cell elongation and formation of stress fibers, increases permeability, pinocytosis and lipoprotein internalization, is involved in the formation of atherosclerotic lesions, increases the production of tissue plasminogen activator, and enhances von Willebrand factor release and hence platelet aggregation. It decreases adherence of erythrocytes and leukocytes, and increases the release of prostacyclin, endothelium derived relaxing factor, histamine and other compounds, but decreases erythropoietin secretion. The mechanism of signal transduction to the endothelial cell is not known exactly; shear-sensitive ion channels seem to be involved. It is concluded that a better understanding of shear-dependent endothelial functions will influence pathophysiologic concepts and therapeutic interventions.

Key words

Adhesion atherosclerosis cytoskeleton endothelium hormones shear thrombosis 

Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • W. H. Reinhart
    • 1
  1. 1.Internal Medicine, KantonsspitalChurSwitzerland

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