Agents and Actions

, Volume 14, Issue 3, pp 543–545

Histamine H2-binding studies in the guinea-pig brain

  • D. B. Norris
  • G. A. Gajtkowski
  • T. J. Rising
Histamine in the Central Nervous System

DOI: 10.1007/BF01973867

Cite this article as:
Norris, D.B., Gajtkowski, G.A. & Rising, T.J. Agents and Actions (1984) 14: 543. doi:10.1007/BF01973867

Abstract

Using3H-mepyramine and3H-tiotidine to label, respectively, the histamine H1- and H2-receptors, we have assessed the distribution of these receptors in five distinct areas of guinea-pig brain.

With regard to the H2-receptor, we could detect no binding in either the cerebellum or pons-medulla, whereas the distribution in the other brain areas was corpus striatum > cortex > hippocampus. This was in contrast to the distribution of the H1-receptor which was found to be in all areas studied but predominantly in the cerebellum.

Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • D. B. Norris
    • 1
  • G. A. Gajtkowski
    • 1
  • T. J. Rising
    • 1
  1. 1.Hoechst Pharmaceutical Research LaboratoriesMilton KeynesUK