Agents and Actions

, Volume 14, Issue 3, pp 397–400

Prostaglandin and histamine release from stimulated rat peritoneal mast cells

  • Madeleine Ennis
  • Susan E. Barrow
  • I. A. Blair
Mechanisms of Histamine Release

DOI: 10.1007/BF01973836

Cite this article as:
Ennis, M., Barrow, S.E. & Blair, I.A. Agents and Actions (1984) 14: 397. doi:10.1007/BF01973836

Abstract

The production of five prostanoids (PGD2, PGE2, PGF, 6-oxo-PGF, and TxB2) was examined after mast cell activation. Prostaglandin D2 (PGD2) was the major prostanoid produced after stimulation of rat peritoneal mast cells with the calcium ionophore A 23187, compound 48/80 or anti-rat IgE. The amount of PGD2 generated was not dependent on the quantity of histamine released. The time course of PGD2 production paralleled the release of histamine following activation with A 23187 or anti-rat IgE but with compound 48/80 release of histamine reached a maximum within 15 sec, whereas production of PGD2 was apparent only after 5 min and was still increasing at 30 min.

Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Madeleine Ennis
    • 1
  • Susan E. Barrow
    • 2
  • I. A. Blair
    • 2
  1. 1.Abteilung für Theoretische Chirurgie, Zentrum für Operative Medizin 1Klinikum der Philipps-Universität MarburgMarburgFRG
  2. 2.Department of Clinical PharmacologyThe Royal Postgraduate Medical School, Hammersmith HospitalLondonUK

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