, Volume 14, Issue 3-4, pp 351-355

N-methyl-N-formylhydrazine: A toxic and mutagenic inhibitor of the intestinal diamine oxidase

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Abstract

N-methyl-N-formylhydrazine is the first active intermediate of the poison gyromitrin of the mushroom: false morel. This compound is a non-competitive inhibitor of human intestinal diamine oxidase (ID50=1.6×10−5 mol/l). This concentration corresponds to less than 5g of wet weight of mushroom/l. The diamine oxidases from 5 other sources are inhibited in a similar manner. Semicarbazide and aminoguanidine are 10-respectively 1000-fold more potent inhibitors of the human intestinal diamine oxidase. An involvement of the diamine oxidase inhibitory property ofN-methyl-N-formylhydrazine in toxic and mutagenic effects of the substance is considered.

Supported by Alexander von Humboldt-Stiftung.
Supported by a grant from Deutsche Forschungsgemeinschaft (Ku 464/1)
To whom request for reprints should be addressed.