The effect of indomethacin on cartilage breakdown
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- Desa, F.M., Chander, C.L., Moore, A.R. et al. Agents and Actions (1989) 27: 485. doi:10.1007/BF01972859
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The effects of recombinant interleukin-1α (rIL-1α) and indomethacin on the glycosaminoglycan (GAG) content of rat femoral head cartilage (FHC) were studiedin vitro. Net GAG loss was observed from cartilage cultured in the presence of indomethacin plus rIL-1α. Indomethacin and rIL-1α alone caused no net loss of GAG from cartilage unless the cartilage was cultured in the presence of fibroblasts.