Agents and Actions

, Volume 27, Issue 3, pp 485–487

The effect of indomethacin on cartilage breakdown

  • F. M. Desa
  • C. L. Chander
  • A. R. Moore
  • D. W. Howat
  • D. G. Corry
  • D. A. Willoughby
Mini-Papers Submitted for Scholarship Competition Proteases and Connective Tissue Breakdown

DOI: 10.1007/BF01972859

Cite this article as:
Desa, F.M., Chander, C.L., Moore, A.R. et al. Agents and Actions (1989) 27: 485. doi:10.1007/BF01972859

Abstract

The effects of recombinant interleukin-1α (rIL-1α) and indomethacin on the glycosaminoglycan (GAG) content of rat femoral head cartilage (FHC) were studiedin vitro. Net GAG loss was observed from cartilage cultured in the presence of indomethacin plus rIL-1α. Indomethacin and rIL-1α alone caused no net loss of GAG from cartilage unless the cartilage was cultured in the presence of fibroblasts.

Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • F. M. Desa
    • 1
  • C. L. Chander
    • 1
  • A. R. Moore
    • 1
  • D. W. Howat
    • 1
  • D. G. Corry
    • 1
  • D. A. Willoughby
    • 1
  1. 1.Department of Experimental PathologySt. Bartholomew's Hospital, Medical CollegeLondonUK