Agents and Actions

, Volume 27, Issue 3, pp 344–346

The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats

Authors

  • B. D. Jaffee
    • Medical Products Department, Experimental StationE. I. Du Pont de Nemours & Co.
  • J. S. Kerr
    • Medical Products Department, Experimental StationE. I. Du Pont de Nemours & Co.
  • E. A. Jones
    • Medical Products Department, Experimental StationE. I. Du Pont de Nemours & Co.
  • J. V. Giannaras
    • Medical Products Department, Experimental StationE. I. Du Pont de Nemours & Co.
  • M. McGowan
    • Medical Products Department, Experimental StationE. I. Du Pont de Nemours & Co.
  • N. R. Ackerman
    • Medical Products Department, Experimental StationE. I. Du Pont de Nemours & Co.
Animal Models

DOI: 10.1007/BF01972818

Cite this article as:
Jaffee, B.D., Kerr, J.S., Jones, E.A. et al. Agents and Actions (1989) 27: 344. doi:10.1007/BF01972818

Abstract

The purpose of this study was to investigate the effects of cyclosporine A (CSA) and methotrexate (MTX) as potential immunomodulators in a nonestablished adjuvant arthritis (AA) model. Non-injected hind paw volumes were reduced when AA rats were treated for 18 dayswith CSA (100% at 10 mg/kg) or MTX (100% at 0.1 mg/kg). Body weights of drug treated AA rats were increased above untreated AA rats and were similar to non-arthritic controls. AA rats show elevated T helper (W3/25+)/T suppressor (OX 8+) cell ratios (2.0 vs. 3.1,p<0.01). The immunomodulators tested all returned these elevated ratios to control non-arthritic levels. Similarly, these drugs returned the reduced mitogen responses and elevated blood granulocyte numbers toward normal non-arthritic control values.

Copyright information

© Birkhäuser Verlag 1989