Distribution, antibiotic susceptibility and tolerance of bacterial isolates in culture-positive cases of endocarditis in The Netherlands

  • J. T. M. van der Meer
  • W. van Vianen
  • E. Hu
  • W. B. van Leeuwen
  • H. A. Valkenburg
  • J. Thompson
  • M. F. Michel
Article

DOI: 10.1007/BF01972497

Cite this article as:
van der Meer, J.T.M., van Vianen, W., Hu, E. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1991) 10: 728. doi:10.1007/BF01972497

Abstract

During a two-year period data were collected nationwide in The Netherlands on 438 episodes of bacterial endocarditis (BE) in 432 patients. Of the strains isolated in these patients 419 were available for analysis. Of these, 326 were isolated in native valve endocarditis (NVE) and 93 in prosthetic valve endocarditis (PVE). Viridans streptococci, staphylococci and enterococci together constituted 87 % of the isolates. More than 46 % of the viridans streptococci consisted ofStreptococcus sanguis. Enterococus faecalis andStaphylococcus aureus were the predominant species in the late form of PVE. The majority of the viridans streptococci and haemolytic streptococci were highly susceptible to penicillin. Five of 35 strains of coagulase negative staphylococci were resistant to methicillin. Eleven percent of a random sample of the streptococci collected were tolerant to penicillin. After repeated exposure to a concentration gradient of an appropriate β-lactam antibiotic, this figure increased to 49 %. Of the staphylococci, 5–6 % of the strains were tolerant before induction and 16–20 % after induction. Of theEnterococcus strains (n=40), 12.5 % showed high-level resistance to one or more aminoglycoside.

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1991

Authors and Affiliations

  • J. T. M. van der Meer
    • 1
  • W. van Vianen
    • 1
  • E. Hu
    • 1
  • W. B. van Leeuwen
    • 1
  • H. A. Valkenburg
    • 2
  • J. Thompson
    • 3
  • M. F. Michel
    • 1
  1. 1.Department of Clinical MicrobiologyErasmus University RotterdamRotterdamThe Netherlands
  2. 2.Department of Epidemiology and BiostatisticsErasmus University RotterdamRotterdamThe Netherlands
  3. 3.Department of Infectious DiseasesLeiden University HospitalLeidenThe Netherlands

Personalised recommendations