The potential role of granulocyte-macrophage colony stimulating factor in therapy of fungal infections: A commentary
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- Bodey, G.P. Eur. J. Clin. Microbiol. Infect. Dis. (1994) 13: 363. doi:10.1007/BF01971991
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In vitro data and clinical studies have demonstrated that GM-CSF reverses granulocytopenia in patients. In animal studies, it also augments the fungicidal activity of neutrophils and monocyte/macrophages. This in vitro effect may correlate with demonstrated clinical benefit, although further studies to determine optimal dosage, and route and time of administration are required. The promising results of the studies carried out to date indicate that this is an area which merits further investigation.