Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes
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- Haraguchi, H., Ohmi, I., Masuda, H. et al. Experientia (1996) 52: 564. doi:10.1007/BF01969729
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Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.