, Volume 52, Issue 6, pp 564-567

Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes

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Abstract

Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.