Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes
- Cite this article as:
- Haraguchi, H., Ohmi, I., Masuda, H. et al. Experientia (1996) 52: 564. doi:10.1007/BF01969729
Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.