Experientia

, Volume 52, Issue 6, pp 564–567

Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes

  • H. Haraguchi
  • I. Ohmi
  • H. Masuda
  • Y. Tamura
  • K. Mizutani
  • O. Tanaka
  • W. -H. Chou
Research Articles

DOI: 10.1007/BF01969729

Cite this article as:
Haraguchi, H., Ohmi, I., Masuda, H. et al. Experientia (1996) 52: 564. doi:10.1007/BF01969729

Abstract

Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.

Key words

Engelhardtia chrysolepisastilbinneoastilbintaxifolinaldose reductasealdehyde reductaseNADH oxidase

Copyright information

© Birkhäuser Verlag 1996

Authors and Affiliations

  • H. Haraguchi
    • 1
  • I. Ohmi
    • 1
  • H. Masuda
    • 2
  • Y. Tamura
    • 2
  • K. Mizutani
    • 2
  • O. Tanaka
    • 2
  • W. -H. Chou
    • 3
  1. 1.Faculty of EngineeringFukuyama UniversityFukuyama(Japan)
  2. 2.Biology and Chemistry LaboratoryMaruzen Pharmaceutical Co. Ltd.Fukuyama(Japan)
  3. 3.South China Institute of BotanyThe Academy of Science of ChinaGuangzhou(China)