Research Articles

Experientia

, Volume 52, Issue 6, pp 564-567

Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes

  • H. HaraguchiAffiliated withFaculty of Engineering, Fukuyama University
  • , I. OhmiAffiliated withFaculty of Engineering, Fukuyama University
  • , H. MasudaAffiliated withBiology and Chemistry Laboratory, Maruzen Pharmaceutical Co. Ltd.
  • , Y. TamuraAffiliated withBiology and Chemistry Laboratory, Maruzen Pharmaceutical Co. Ltd.
  • , K. MizutaniAffiliated withBiology and Chemistry Laboratory, Maruzen Pharmaceutical Co. Ltd.
  • , O. TanakaAffiliated withBiology and Chemistry Laboratory, Maruzen Pharmaceutical Co. Ltd.
  • , W. -H. ChouAffiliated withSouth China Institute of Botany, The Academy of Science of China

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Abstract

Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.

Key words

Engelhardtia chrysolepis astilbin neoastilbin taxifolin aldose reductase aldehyde reductase NADH oxidase