Antibiotics in Gynaecology and Obstetrics

Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 292-295

First online:

Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin
  • W. K. BrouwerAffiliated withMedical Centre Leeuwarden
  • , K. M. KuiperAffiliated withMedical Centre Leeuwarden
  • , J. A. A. Hoogkamp-KorstanjeAffiliated withLaboratory for Public Health

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The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.


Cefuroxime Ciprofloxacin Drug therapy Hysterectomy Metronidazole Pre-operative care