Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 292–295

Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin


  • W. K. Brouwer
    • Medical Centre Leeuwarden
  • K. M. Kuiper
    • Medical Centre Leeuwarden
  • J. A. A. Hoogkamp-Korstanje
    • Laboratory for Public Health
Antibiotics in Gynaecology and Obstetrics

DOI: 10.1007/BF01967836

Cite this article as:
Brouwer, W.K., Kuiper, K.M. & Hoogkamp-Korstanje, J.A.A. Pharmaceutisch Weekblad Scientific Edition (1990) 12: 292. doi:10.1007/BF01967836


The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.


CefuroximeCiprofloxacinDrug therapyHysterectomyMetronidazolePre-operative care

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990