Antibiotics in Gynaecology and Obstetrics

Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 292-295

First online:

Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin
  • W. K. BrouwerAffiliated withMedical Centre Leeuwarden
  • , K. M. KuiperAffiliated withMedical Centre Leeuwarden
  • , J. A. A. Hoogkamp-KorstanjeAffiliated withLaboratory for Public Health

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.


Cefuroxime Ciprofloxacin Drug therapy Hysterectomy Metronidazole Pre-operative care