European Journal of Clinical Microbiology and Infectious Diseases

, Volume 11, Issue 2, pp 125–130

Cotrimoxazole therapy ofToxoplasma gondii encephalitis in AIDS patients


  • A. Canessa
    • Department of Infectious DiseasesUniversity of Genoa
  • V. Del Bono
    • Department of Infectious DiseasesUniversity of Genoa
  • P. De Leo
    • Department of Infectious DiseasesUniversity of Genoa
  • N. Piersantelli
    • Division of Infectious DiseasesGalliera Hospital
  • A. Terragna
    • Department of Infectious DiseasesUniversity of Genoa

DOI: 10.1007/BF01967063

Cite this article as:
Canessa, A., Del Bono, V., De Leo, P. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1992) 11: 125. doi:10.1007/BF01967063


Twenty-four consecutive HIV-positive patients affected byToxoplasma gondii encephalitis received trimethoprim-sulfamethoxazole (cotrimoxazole) as acute-phase treatment. Two dosage regimens of cotrimoxazole were used: 40 mg/kg/day (12 patients) or 120 mg/kg/day (12 patients) of total compound (trimethoprim plus sulfamethoxazole). Clinical and radiological responses to treatment were evaluated, and the product-limit method for survival data analysis was used. Eighteen of 24 patients showed both a clinical and radiological response (75 % response rate). There were no differences in response rates between patients receiving the two dosage regimens of cotrimoxazole. Adverse reaction consisted of leukopenia (two cases) and skin rash (three cases) which led to the discontinuation of the drug in one case. These results suggest that a randomized, controlled clinical trial should be carried out comparing cotrimoxazole versus sulfadiazine-pyrimethamine in AIDS patients withToxoplasma gondii encephalitis.

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© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992