Article

European Journal of Clinical Microbiology and Infectious Diseases

, Volume 11, Issue 2, pp 99-109

Fungal infections in cancer patients: An international autopsy survey

  • G. BodeyAffiliated withM.D. Anderson Cancer Center
  • , B. BueltmannAffiliated withUniversity of Ulm
  • , W. DuguidAffiliated withMontreal General Hospital
  • , D. GibbsAffiliated withPfizer International, Inc.
  • , H. HanakAffiliated withHanusch Hospital
  • , M. HotchiAffiliated withShinshu University Hospital
  • , G. MallAffiliated withUniversity of Heidelberg
  • , P. MartinoAffiliated withUniversity La Sapienza
  • , F. MeunierAffiliated withEORTC
    • , S. MillikenAffiliated withM.D. Anderson Cancer CenterRoyal Marsden Hospital
    • , S. NaoeAffiliated withM.D. Anderson Cancer CenterToho University
    • , M. OkudairaAffiliated withM.D. Anderson Cancer CenterKitazato University
    • , D. ScevolaAffiliated withM.D. Anderson Cancer CenterUniversity of Pavia
    • , J. van't WoutAffiliated withM.D. Anderson Cancer CenterLeiden University

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Abstract

In an attempt to estimate the frequency of fungal infections among cancer patients, a survey of autopsy examinations was conducted in multiple institutions in Europe, Japan and Canada. Fungal infections were identified most often in leukemic patients and transplant recipients (25 % each). Fifty-eight percent of fungal infections were caused byCandida spp. and 30 % byAspergillus spp. There was considerable variability in the frequency of fungal infections in different countries. Nevertheless, this study clearly demonstrates that fungal infections represent a common complication in cancer patients, especially in patients with leukemia.