, Volume 36, Issue 5, pp 601-603

Cellular events in denervated limb stumps ofAmbystoma larvae during re-innervation and subsequent regeneration

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Amputated, denervatedAmbystoma forelimbs undergo cellular dedifferentiation and slight resorption through 12 days post-amputation. Subsequently, as limb stumps become re-innervated, there occur mitosis, blastema formation, and regeneration. The initial increase in the mitotic index in once-denervated limb stumps is closely correlated with the presence of ingrowing nerve fibres.

This work was supported by grant PCM 76-11807 from the National Science Foundation.