Unusual in vitro formation of cyst-like structures associated with human intestinal spirochaetosis
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Spirochaetes were isolated from rectal biopsies of three patients and successfully cultured. Enzymatic reactions and electron microscopy revealed spirochaetes resemblingBrachyspira aalborgi. Examination of ultrathin sections of centrifugates of cultured spirochaetes yielded unusual cyst-like structures with an outer double membrane containing spirochaetes in different developmental stages. The protoplasmic cylinders seemed to originate from a large electrondense focus in the cyst-like structures. The axial fibrils occurred as loosely distributed solitary structures in the cyst-like structures. Cysts were not found in the biopsy tissue. The encystment of the spirochaetes could be related to their protection, multiplication, spread and transmission.
- Harland, W. A., Lee, F. D. Intestinal spirochaetosis. British Medical Journal 1967, iii: 718–719.
- Anonymous: Intestinal spirochaetes. Lancet 1984, i: 720.
- Lee, F. D., Kraszewski, A., Gordon, I., Howie, J. G. R., McSeveney, D., Harland, W. A. Intestinal spirochaetosis. Gut 1971, 12: 126–133.
- Takeuchi, A., Jervis, H. R., Nakazawa, H., Robinson, D. M. Spiral-shaped organisms on the surface colonic epithelium of the monkey and man. American Journal of Clinical Nutrition 1974, 27: 1287–1296.
- Henrik-Nielsen, R., Orholm, M., Pedersen, J. O., Hovind-Hougen, K., Teglbjaerg, P. S., Thaysen, E. H. Colorectal spirochetosis: clinical significance of the infestation. Gastroenterology 1983, 85: 62–67.
- Gebbers, J.-O., Ferguson, D. J. P., Mason, C., Kelly, P., Jewell, D. P. Spirochaetosis of the human rectum associated with an intraepithelial mast cell and IgE plasma cell response. Gut 1987, 28: 588–593.
- Gebbers, J.-O., Ferguson, D. J. P., Mason, C., Crucioli, V., Jewell, D. P. Lokale Immunreaktion bei intestinaler Spirochätose des Menschen. Schweizerische Medizinische Wochenschrift 1987, 117: 1087–1091.
- McMillan, A., Lee, F. D. Sigmoidoscopic and microscopic appearance of the rectal mucosa in homosexual men. Gut 1981, 22: 1035–1041.
- Hovind-Hougen, K., Birch-Andersen, A., Henrik-Nielsen, R., Orholm, M., Pedersen, J. O., Teglbjaerg, P. S., Thaysen, E. H. Intestinal spirochetosis: morphological characterization and cultivation of the spirocheteBrachyspira aalborgi gen. nov., sp. nov. Journal of Clinical Microbiology 1982, 16: 1127–1136.
- Umemoto, T., Namikawa, I., Yoshii, Z., Konishi, H. An internal view of the spherical body ofTreponema macrodentium as revealed by scanning electron microscopy. Microbiology and Immunology 1982, 26: 191–198.
- Al-Qudah, A. A., Mostratos, A., Quesnel, L. B. A proposed life cycle for the Reiter treponeme. Journal of Applied Bacteriology 1983, 55: 417–428.
- Bessemans, A., Wittebolie, P., Baert, H. Study by means of micromanipulation of the virulence of one or several spirochaetes as well as viability of spirochaetes or granular forms of culture of supposedTreponema pallidum. Bulletin of Hygiene 1947, 23: 548–559.
- Wile, U. J. Transmission of experimental syphilis from mouse to mouse in absence ofTreponema pallida and of pathologic changes in presence of successful inoculation. American Journal of Syphilis, Gonorrhoea and Venereal Diseases 1947, 81: 109–114.
- Unusual in vitro formation of cyst-like structures associated with human intestinal spirochaetosis
European Journal of Clinical Microbiology and Infectious Diseases
Volume 8, Issue 4 , pp 302-306
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