, Volume 39, Issue 4, pp 408-409

Chronic infections in laboratory rodents from inoculation of nonencapsulated plague bacilli (Yersinia pestis)

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Summary

Infections with nonencapsulatedY. pestis persisted for 9 weeks in mice and 56 weeks in rats after experimental inoculation. Mice succumbed with bacteremia. Rats developed chronic lesions containing nonencapsulated plague bacilli.

In conducting the research described in this report, the investigators adhere to the ‘Guide for the Care and Use of Laboratory Animals’; as promulgated by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council.