Experientia

, Volume 44, Issue 9, pp 762–764

Enantiomeric cannabinoids: stereospecificity of psychotropic activity

  • R. Mechoulam
  • J. J. Feigenbaum
  • N. Lander
  • M. Segal
  • T. U. C. Järbe
  • A. J. Hiltunen
  • P. Consroe
Short Communications

DOI: 10.1007/BF01959156

Cite this article as:
Mechoulam, R., Feigenbaum, J.J., Lander, N. et al. Experientia (1988) 44: 762. doi:10.1007/BF01959156

Summary

The 1,1-dimethylheptyl homolog of (−)-(3R,4R)-7-hydroxy-delta-6-tetrahydrocannabinol (compoundII) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

Key words

Cannabinoidsstereospecificitypsychotropic activitydrug discrimination

Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • R. Mechoulam
    • 1
    • 2
    • 3
  • J. J. Feigenbaum
    • 1
    • 2
    • 3
  • N. Lander
    • 1
    • 2
    • 3
  • M. Segal
    • 1
    • 2
    • 3
  • T. U. C. Järbe
    • 1
    • 2
    • 3
  • A. J. Hiltunen
    • 1
    • 2
    • 3
  • P. Consroe
    • 1
    • 2
    • 3
  1. 1.Brettler Medical Research Center, Faculty of MedicineHebrew UniversityJerusalem(Israel)
  2. 2.Departments of Psychology and Applied PsychologyUniversity of UppsalaUppsala(Sweden)
  3. 3.Department of Pharmacology and Toxicology, College of PharmacyUniversity of ArizonaTucsonUSA