Experientia

, Volume 47, Issue 3, pp 254–257

4-Aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices

  • H. Olpe
  • C. N. Kolb
  • A. Hausdorf
  • H. L. Haas
Research Articles

DOI: 10.1007/BF01958152

Cite this article as:
Olpe, H., Kolb, C.N., Hausdorf, A. et al. Experientia (1991) 47: 254. doi:10.1007/BF01958152

Summary

The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuated by the potassium-channel blockers barium chloride (0.1 mM) and 4-aminopyridine (200 μM), which suggested that potassium fluxes might be involved in the mechanism of action of carbamazepine.

Key words

Carbamazepinepotassiumhippocampusepilepsyelectrophysiology4-aminopyridine

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • H. Olpe
    • 1
  • C. N. Kolb
    • 1
  • A. Hausdorf
    • 1
  • H. L. Haas
    • 2
  1. 1.Research and Development Department, Pharmaceuticals DivisionCiba-Geigy Ltd.Basel(Switzerland)
  2. 2.Department of PhysiologyUniversity of MainzMainz(Federal Republic of Germany)