European Journal of Pediatrics

, Volume 152, Issue 11, pp 928–930

Endogenous fibrinolysis in neonatal cerebrospinal fluid

  • A. Whitelaw

DOI: 10.1007/BF01957533

Cite this article as:
Whitelaw, A. Eur J Pediatr (1993) 152: 928. doi:10.1007/BF01957533


Although many infants with intraventricular haemorrhage (IVH) recover without hydrocephalus, little is known about how blood is cleared from the CSF pathways. Fibrinolytic activity was measured by the fibrin plate method in CSF from 11 normal infants and 17 infants with IVH. Normal CSF showed no fibrinolytic activity. All the samples taken less than 17 days from diagnosis of IVH samples taken between 17 and 60 days of IVH showed fibrinolytic activity. In 1 infant where 14 serial samples were taken, there was no detectable fibrinolysis up to 16 days after IVH but from 19 to 52 days there was definite fibrinolytic activity. Delayed endogenous fibrinolysis in the CSF is common after IVH but may, in some cases, be insufficient to prevent hydrocephalus.

Key words

Fibrinolysis Cerebrospinal fluid Hydrocephalus Intraventricular haemorrhage Newborn infant 



fibrin degradation product


intraventricular haemorrhage

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • A. Whitelaw
    • 1
  1. 1.Paediatric DepartmentAker University HospitalOsloNorway