, Volume 153, Issue 12, pp 903-905

Pulmonary effects of closure of patent ductus arteriosus in premature infants with severe respiratory distress syndrome

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Infants with severe respiratory disease requiring high ventilation pressure and high oxygen concentration, where structural changes in the lungs are already established, will rarely show short-term improvement in pulmonary disease as a result of closure of a PDA. The overall clinical condition may, however, improve as a result of reduced cardiovascular strain. Earlier treatment of a PDA could reduce the ventilation period and the possible risk of developing chronic lung disease.