European Journal of Pediatrics

, Volume 152, Issue 9, pp 747–749

Antipyretic effectiveness of acetaminophen in febrile seizures: Ongoing prophylaxis versus sporadic usage

Authors

  • D. Schnaiderman
    • Paediatric Division, Assaf Harofeh Medical Centre, Sackler School of MedicineTel Aviv University
  • E. Lahat
    • Paediatric Division, Assaf Harofeh Medical Centre, Sackler School of MedicineTel Aviv University
  • T. Sheefer
    • Paediatric Division, Assaf Harofeh Medical Centre, Sackler School of MedicineTel Aviv University
  • M. Aladjem
    • Paediatric Division, Assaf Harofeh Medical Centre, Sackler School of MedicineTel Aviv University
Neuropediatrics

DOI: 10.1007/BF01953992

Cite this article as:
Schnaiderman, D., Lahat, E., Sheefer, T. et al. Eur J Pediatr (1993) 152: 747. doi:10.1007/BF01953992

Abstract

A controlled clinical study compared the antipyretic effectiveness of acetaminophen administered at regular 4 h intervals (group 1,n=53) versus sproadic usage contingent upon a body temperature above 37.9°C (group 2,n=51) in 104 children presenting with simple febrile convulsions. The incidence of febrile episodes or temperature values were similar in spite of significantly larger amounts of acetaminophen administered to patients in group 1. Four and 4 children in groups 1 and 2, respectively, had a second episode of febrile seizures, in all of them within the first 24 h of admission. We conclude that the prophylactic administration of acetaminophen in children with febrile seizures is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of febrile seizures.

Key words

Febrile seizures Acetaminophen

Abbreviation

FS

febrile seizures

Copyright information

© Springer-Verlag 1993