, Volume 35, Issue 12, pp 1657–1658

Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis

  • G. A. Turner

DOI: 10.1007/BF01953252

Cite this article as:
Turner, G.A. Experientia (1979) 35: 1657. doi:10.1007/BF01953252


The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • G. A. Turner
    • 1
  1. 1.Royal Victoria InfirmaryUniversity Department of Clinical BiochemistryNewcastle upon Tyne(England)
  2. 2.Department Experimental PathologyRoswell Park Memorial InstituteBuffaloUSA)