Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis
- Cite this article as:
- Turner, G.A. Experientia (1979) 35: 1657. doi:10.1007/BF01953252
The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.