, Volume 42, Issue 11-12, pp 1242-1244

Dopamine in the visual cortex of the cat

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The endogenous content of noradrenaline (NA) and dopamine (DA) was determined by radioenzymatic assays in three different areas of the occipital (visual) cortex, in normal cats as well as in DA-deafferented animals. The use of HPLC methodology enabled us to detect and measure in addition two metabolites of DA: 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), thus confirming the existence of a DA innervation in this cortical region.

Acknowledgments. This work was supported by grants from the Medical Research Council of Canada (MT-6967 to TAR) and the Savoy Foundation for Epilepsy (TAR and LFQ). The authors also thank Mrs C. Mercure and L. Grondin for technical assistance. Dr Reader is a member of the Equipe de Recherche sur les Neurotransmetteurs du Cerveau and Chercheur-boursier Senior; Fonds de la recherche en Santé du Québec.