Experientia

, Volume 51, Issue 12, pp 1175–1188

Cell adhesion in the life cycle ofDictyostelium

  • S. Bozzaro
  • E. Ponte
Multi-author Reviews

DOI: 10.1007/BF01944735

Cite this article as:
Bozzaro, S. & Ponte, E. Experientia (1995) 51: 1175. doi:10.1007/BF01944735

Abstract

three forms of cell adhesion determine the life cycle ofDictyostelium: i) adhesion of bacteria to the surface of the growing amoebae, as the prerequisite for phagocytosis;ii) cell-substrate adhesion, necessary for both locomotion of the amoebae and migration of the slug;iii) cell-cell adhesion, essential for transition from the unicellular to the multicellular stage. Intercellular adhesion has received the most attention, and fruitful approaches have been developed over the past 25 years to identify, purify and characterize cell adhesion molecules. The csA glycoprotein, in particular, which mediates adhesion during the aggregation stage, is one of the best defined cell adhesion molecules. The molecular components involved in phagocytosis and cell-substratum adhesion are less well understood, but the basis has been laid for a systematic investigation of both topics in the near future.

Key words

Dictyostelium Polysphondylium slime mold cell adhesion phagocytosis cell differentiation morphogenesis immobilized ligands membrane glycoproteins cytoskeleton 

Copyright information

© Birkhäuser Verlag Basel 1995

Authors and Affiliations

  • S. Bozzaro
    • 1
  • E. Ponte
    • 1
  1. 1.Department of Clinical and Biological SciencesUniversity of TurinOrbassano-Torino(Italy)