Experientia

, Volume 44, Issue 10, pp 880–881

Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids fromTrypanosoma cruzi

  • E. G. Díaz de Toranzo
  • J. A. Castro
  • B. M. Franke de Cazzulo
  • J. J. Cazzulo
Short Communications

DOI: 10.1007/BF01941187

Cite this article as:
Díaz de Toranzo, E.G., Castro, J.A., Franke de Cazzulo, B.M. et al. Experientia (1988) 44: 880. doi:10.1007/BF01941187

Summary

Epimastigotes ofTrypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazone acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.

Key words

Trypanosoma cruzibenznidazoleChagas' diseaseAmerican trypanosomiasischemotherapy

Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • E. G. Díaz de Toranzo
    • 1
  • J. A. Castro
    • 1
  • B. M. Franke de Cazzulo
    • 2
  • J. J. Cazzulo
    • 2
  1. 1.Centro de Investigaciones Toxicológicas (CEITOX)CITEFA/CONICETVilla Martelli, Pcia de Buenos Aires(Argentina)
  2. 2.Instituto de Investigaciones Bioquímicas Fundción CampomarBuenos Aires(Argentina)