Experientia

, Volume 44, Issue 5, pp 383–389

Multifunctional interneurons in behavioral circuits of the medicinal leech

Authors

  • W. B. KristanJr
    • Department of Biology, B-022University of California
  • G. Wittenberg
    • Department of Biology, B-022University of California
  • M. P. Nusbaum
    • Department of BiologyBrandeis University
  • W. Stern-Tomlinson
    • Department of Biology, B-022University of California
Reviews

DOI: 10.1007/BF01940531

Cite this article as:
Kristan, W.B., Wittenberg, G., Nusbaum, M.P. et al. Experientia (1988) 44: 383. doi:10.1007/BF01940531

Summary

We are using the medicinal leech to study the neuronal basis of behavioral choice. In particular, we are recording from neurons, both extracellularly and intracellularly, in preparations that can express three different behaviors: the shortening reflex, crawling and swimming. We have found that particular mechanosensory neurons can elicit any of the behaviors, and that the movements are produced by just four sets of muscles, each controlled by a small number of motor neurons. Hence, there must be three different pattern-generating neuronal circuits, each of which can be activated by the same set of sensory neurons. We are studying how the choice is made among the three behaviors by recording, while one behavior is being performed, from neurons known to be involved in the initiation of the other two. We have found that an interneuron, cell 204, which is known to initiate and maintain swimming, is also active during shortening and crawling. The activity level in this interneuron can influence whether a mechanosensory stimulus produces shortening or swimming. The neuronal mechanisms by which this choice is normally effected awaits further elucidation of the circuits that elicit and generate shortening and crawling.

Key words

Behavioral statecommand neurongating neuronleechmechanosensory neuronmotor neuronpattern-generating neuronrhythmic motor patternshortening reflextrigger neuron

Copyright information

© Birkhäuser Verlag 1988