A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice
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- Burstein, S., Hunter, S.A., Latham, V. et al. Experientia (1987) 43: 402. doi:10.1007/BF01940427
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The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.