Experientia

, Volume 43, Issue 4, pp 402–403

A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

Authors

  • S. Burstein
    • Department of BiochemistryUniversity of Massachusetts Medical School
  • S. A. Hunter
    • Department of BiochemistryUniversity of Massachusetts Medical School
  • V. Latham
    • Department of BiochemistryUniversity of Massachusetts Medical School
  • L. Renzulli
    • Department of BiochemistryUniversity of Massachusetts Medical School
Short Communications

DOI: 10.1007/BF01940427

Cite this article as:
Burstein, S., Hunter, S.A., Latham, V. et al. Experientia (1987) 43: 402. doi:10.1007/BF01940427

Summary

The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.

Key words

Δ1-tetrahydrocannabinolmetabolitesantagonists

Copyright information

© Birkhäuser Verlag 1987