Short Communications

Experientia

, Volume 43, Issue 4, pp 402-403

First online:

A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

  • S. BursteinAffiliated withDepartment of Biochemistry, University of Massachusetts Medical School
  • , S. A. HunterAffiliated withDepartment of Biochemistry, University of Massachusetts Medical School
  • , V. LathamAffiliated withDepartment of Biochemistry, University of Massachusetts Medical School
  • , L. RenzulliAffiliated withDepartment of Biochemistry, University of Massachusetts Medical School

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.

Key words

Δ1-tetrahydrocannabinol metabolites antagonists