, Volume 32, Issue 11, pp 1467-1468

The origin of experimental brain tumours: A sequential study

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Summary

A sequential study of rat brains treated transplacentally with the neurotropic carcinogen ethylnitrosourea reveals small foci of cell proliferations from the age of 8 weeks. These lesions consist mainly of undifferentiated cells of the subependymal plate type. They occur in those areas in which gliomas develop and represent the earliest, histologically detectable, changes in the development of brain tumours.

Acknowledgments. We thank Dr.Helen C. Grant for her help in preparation of this manuscript andG. J. Pilkington andA. L. E. Barron for their skilful technical assistance.