Experientia

, Volume 33, Issue 1, pp 70–71

The local anesthetic potency of norcocaine, a metabolite of cocaine

Authors

  • W. W. Just
    • Arbeitsgruppe NeurochemieMax-Planck-Institut für Hirnforschung
    • Institut für allgemeine und vergleichende Physiologie der Universität Wien
  • J. Hoyer
    • Arbeitsgruppe NeurochemieMax-Planck-Institut für Hirnforschung
    • Institut für allgemeine und vergleichende Physiologie der Universität Wien
Article

DOI: 10.1007/BF01936761

Cite this article as:
Just, W.W. & Hoyer, J. Experientia (1977) 33: 70. doi:10.1007/BF01936761

Summary

The local anesthetic effects of cocaine and one of its main metabolites norcocaine, were investigated comparatively on isolated ganglion cells of the marine gastropod,Aplysia californica. During a 1-hour-period, different action potential parameters such as amplitude, duration, maximum rate of rise were observed, which demonstrated that norcocaine exhibits a higher local anesthetic potency than cocaine.

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Copyright information

© Birkhäuser Verlag 1977