, Volume 33, Issue 1, pp 70-71

The local anesthetic potency of norcocaine, a metabolite of cocaine

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The local anesthetic effects of cocaine and one of its main metabolites norcocaine, were investigated comparatively on isolated ganglion cells of the marine gastropod,Aplysia californica. During a 1-hour-period, different action potential parameters such as amplitude, duration, maximum rate of rise were observed, which demonstrated that norcocaine exhibits a higher local anesthetic potency than cocaine.