Experientia

, Volume 33, Issue 12, pp 1657–1659

Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators

  • F. Awouters
  • C. J. E. Niemegeers
  • J. Van den Berk
  • J. M. Van Nueten
  • F. M. Lenaerts
  • M. Borgers
  • K. H. L. Schellekens
  • A. Broeckaert
  • J. De Cree
  • P. A. J. Janssen
Specialia Haematologica, Immunologica

DOI: 10.1007/BF01934056

Cite this article as:
Awouters, F., Niemegeers, C.J.E., Van den Berk, J. et al. Experientia (1977) 33: 1657. doi:10.1007/BF01934056

Summary

Oxatomide is a new potent inhibitor of anaphylactic and allergic reactions. After oral administration, the compound both inhibits the release of endogenous histamine and prevents the effects of exogenous histamine, at comparable doses. The combination of these effects appears to be the basis of the effectiveness of oxatomide in allergic reactions and may lead to clinical applications different from classical antihistaminics and from cromoglycate.

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • F. Awouters
    • 1
  • C. J. E. Niemegeers
    • 1
  • J. Van den Berk
    • 1
  • J. M. Van Nueten
    • 1
  • F. M. Lenaerts
    • 1
  • M. Borgers
    • 1
  • K. H. L. Schellekens
    • 1
  • A. Broeckaert
    • 1
  • J. De Cree
    • 1
  • P. A. J. Janssen
    • 1
  1. 1.Research LaboratoriaJanssen PharmaceuticaBeerseBelgium