Experientia

, Volume 52, Issue 2, pp 115–119

Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats

  • K. T. Augusti
  • C. G. Sheela
Research Articles

DOI: 10.1007/BF01923354

Cite this article as:
Augusti, K.T. & Sheela, C.G. Experientia (1996) 52: 115. doi:10.1007/BF01923354

Abstract

Treatment of alloxan diabetic rats with the antioxidant S-allyl cysteine sulfoxide (SACS) isolated from garlic (Allium sativum Linn)., ameliorated the diabetic condition almost to the same extent as did glibenclamide and insulin. In addition, SACS controlled lipid peroxidation better than the other two drugs. Furthermore, SACS significantly stimulated in vitro insulin secretion from B cells isolated from normal rats. Hence it can be surmised that the beneficial effects of SACS could be due to both its antioxidant and its secretagogue actions. The former effect is more predominant and the latter is only secondary. These effects highlight the therapeutic value of garlic, which is a component of many diets.

Key words

AntioxidantS-ally cysteine sulfoxideinsulin secretagoguealbino ratsglibenclamidemalondialdehydehydroperoxidesupperoxide dismutase

Copyright information

© Birkhäuser Verlag Basel 1996

Authors and Affiliations

  • K. T. Augusti
    • 1
  • C. G. Sheela
    • 1
  1. 1.Department of BiochemistryUniversity of KeralaThiruvananthapuram(India)
  2. 2.School of Medical Educationm.G. University CentreKottayam(India)