, Volume 34, Issue 3, pp 384-385

Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities

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Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1–0.5 mM, but inhibited by higher concentrations.

Acknowledgment. Supported by a grant from the Orion and Medica Scientific Foundation, Finland.