, Volume 52, Issue 1, pp 5-13

The history of cyclosporin A (Sandimmune®) revisited: Another point of view

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Abstract

The immunosuppressant cyclosporin A (Sandimmune®) has become the first line treatment for preventing rejection of transplanted organs and for certain, autoimmune diseases. The discovery of that drug and its preclinical development are described, and it is shown that most earlier accounts of the history of this compound are, in important respects, incorrect and misleading.