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Diterpene esters from ‘Euphorbium’ and their irritant and cocarcinogenic activity

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  • Pharmacologica
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Zusammenfassung

Aus «Euphorbium», dem luftgetrockneten Latex vonEuphorbia resinifera Berg, wurden 2 neue Ester des tri- und makrozyklischen, polyfunktionellen Diterpens Ingol, 2 neue und ein bereits bekannter Ester des tetrazyklischen polyfunktionellen Diterpens 12-Desoxy-phorbol sowie ein Gemisch von neuen Estern des tetrazyklischen polyfunktionellen Diterpens Ingenol isoliert. Das Gemisch der Ingenolester enthält langkettige, methylverzweigte Fettsäuren. Alle isolierten Ester wurden auf irritierende Wirkung am Mäuseohr und auf cocarcinogene Wirkung an der Rückenhaut der Maus geprüft.

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Author notes

  1. S. Kusumoto

    Present address: Faculty of Science, Osaka University, Machikaneyama-cho 1-1, Toyonaka, 560, Osaka, Japan

Authors and Affiliations

  1. Deutsches Krebsforschungszentrum, Institut für Biochemie, Im Neuenheimer Feld 280, D-69, Heidelberg 1, Federal Republic of Germany

    M. Hergenhahn, S. Kusumoto & E. Hecker

Authors
  1. M. Hergenhahn
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  2. S. Kusumoto
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  3. E. Hecker
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Additional information

Dedicated to Prof.H. Hamperi, emeritus director of the Institute of Pathology, University of Bonn, Germany, on occasion of his 75 th birthday (E.H.)

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Hergenhahn, M., Kusumoto, S. & Hecker, E. Diterpene esters from ‘Euphorbium’ and their irritant and cocarcinogenic activity. Experientia 30, 1438–1440 (1974). https://doi.org/10.1007/BF01919683

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  • DOI: https://doi.org/10.1007/BF01919683

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