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Modulation by estradiol of rabbit atrial chronotropic response to histamine

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Summary

The chronotropic response (Δ rate) to histamine of atria from estradiol 17-β (E2; 0.1 mg/kg)-treated (14 days) rabbit was significantly greater compared to those from control rabbits. However, the maximum response of atria from rabbits treated with a higher dose of E2 (1.0 mg/kg) was not significantly different from control. Cimetidine (2.8×10−7 M) inhibited the theoretical maximum increase in rate to histamine in all 3 groups, control 25%, E2 (0.1 mg) 42% and E2 (1.0 mg) 35%.

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References

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Author notes

  1. S. N. Baksi

    Present address: Department of Physiology, Texas Tech. University Health Sciences Center, School of Medicine, 4th Street at Indiana Avenue, 79430, Lubbock, Texas, (USA)

Authors and Affiliations

  1. Department of Physiology, Texas Tech. University Health Sciences Center, School of Medicine, 4th Street at Indiana Avenue, 79430, Lubbock, Texas, (USA)

    M. J. Hughes

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  1. S. N. Baksi
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  2. M. J. Hughes
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Baksi, S.N., Hughes, M.J. Modulation by estradiol of rabbit atrial chronotropic response to histamine. Basic Res Cardiol 78, 505–509 (1983). https://doi.org/10.1007/BF01906461

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  • DOI: https://doi.org/10.1007/BF01906461

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