Immunogenetics

, Volume 7, Issue 1, pp 213–230

Immunoglobulin isoantigens (allotypes) in the mouse

V. Characterization of IgM allotypes
  • Samuel J. Black
  • James W. Goding
  • George A. Gutman
  • Leonard A. Herzenberg
  • Michael R. Loken
  • Barbara A. Osborne
  • Wessel van der Loo
  • Noel L. Warner
Original Investigations

DOI: 10.1007/BF01844009

Cite this article as:
Black, S.J., Goding, J.W., Gutman, G.A. et al. Immunogenetics (1978) 7: 213. doi:10.1007/BF01844009

Abstract

Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound μ chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.

Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Samuel J. Black
    • 1
  • James W. Goding
    • 2
  • George A. Gutman
    • 2
  • Leonard A. Herzenberg
    • 1
  • Michael R. Loken
    • 1
  • Barbara A. Osborne
    • 1
  • Wessel van der Loo
    • 1
  • Noel L. Warner
    • 2
  1. 1.Department of GeneticsStanford University School of MedicineStanford
  2. 2.The Walter and Eliza Hall Institute of Medical ResearchVictoriaAustralia