Immunoglobulin isoantigens (allotypes) in the mouse
- Cite this article as:
- Black, S.J., Goding, J.W., Gutman, G.A. et al. Immunogenetics (1978) 7: 213. doi:10.1007/BF01844009
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Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound μ chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.