Acta Neurochirurgica

, Volume 104, Issue 1, pp 13–16

Uptake of Adriamycin in tumour and surrounding brain tissue in patients with malignant gliomas

Authors

  • H. von Holst
    • Department of NeurosurgeryLudwig Institute for Cancer Research
  • E. Knochenhauer
    • Department of Clinical PharmacologyLudwig Institute for Cancer Research
  • H. Blomgren
    • Department of OncologyLudwig Institute for Cancer Research
  • V. P. Collins
    • Department of Branch and Tumour PathologyKarolinska Hospital
  • L. Ehn
    • Department of OncologyLudwig Institute for Cancer Research
  • M. Lindquist
    • Department of NeuroradiologyKarolinska Hospital
  • G. Norén
    • Department of NeurosurgeryLudwig Institute for Cancer Research
  • C. Peterson
    • Department of Clinical PharmacologyLudwig Institute for Cancer Research
Clinical Research

DOI: 10.1007/BF01842886

Cite this article as:
von Holst, H., Knochenhauer, E., Blomgren, H. et al. Acta neurochir (1990) 104: 13. doi:10.1007/BF01842886

Summary

Eight patients with malignant gliomas verified on CT scan, received an intravenous injection of 50 mg of Adriamycin R, 24 hours prior to surgical removal of the tumour. Peroperatively, both tumour and surrounding tissue specimens were obtained for determination of the tissue concentrations of Adriamycin and its reduced metabolite Adriamycinol. It was found that Adriamycin could be detected in tumour tissue from all patients. The concentration varied between 0,9 and 4,6 nmol/g tissue. In contrast, Adriamycin could only be detected in surrounding brain tissue from one patient.

In anin vitro study a human malignant glioma cell line (U-251 MG) was exposed to various concentrations of Adriamycin for 24 hours. It was found that an intracellular drug concentration above 30 nmol/g cells caused a concentration dependent inhibition of cell growth. Thus, it is likely that the poor effect of Adriamycin on patients with malignant gliomas is due to an ineffective drug accumulation in the tumour tissue.

Keywords

Adriamycinmalignant gliomasglioblastomachemotherapytissue concentration

Copyright information

© Springer-Verlag 1990