Human papillomavirus in breast cancer
- Cite this article as:
- Di Lonardo, A., Venuti, A. & Marcante, M.L. Breast Cancer Res Tr (1992) 21: 95. doi:10.1007/BF01836955
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Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and thein situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences byin situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.