Clinical Autonomic Research

, Volume 2, Issue 1, pp 5–15

Effects of chronic amitriptyline administration on saliva from the parotid and submandibular glands of the rat

  • Jia-Huey Yu
Research Papers

DOI: 10.1007/BF01824205

Cite this article as:
Yu, JH. Clinical Autonomic Research (1992) 2: 5. doi:10.1007/BF01824205


The effect of prolonged treatment with amitriptyline on the secretory activity of rat salivary glands evoked by parasympathetic nerve stimulation and isoprenaline administration has been studied. Low doses of amitriptyline (10 mg/kg per day for 2 or 4 weeks), did not significantly affect salivary flow evoked by either parasympathetic nerve or isoprenaline stimulation. Higher doses of amitriptyline (50 mg/kg/day for 2 or 4 weeks) however, markedly decreased parasympathetic-evoked salivary secretion (flow and volume) from both parotid and submandibular glands, while isoprenaline-evoked secretions were unaffected. Sodium, potassium, and calcium concentrations of nerve-elicited or isoprenaline-evoked saliva were not significantly altered by amitriptyline treatment. Protein concentration and amylase activity of nerve-elicited parotid saliva were, however, greatly increased by chronic amitriptyline administration. Possible mechanisms for drug-induced increase in nerveelicited salivary protein concentration include changes in cholinergic receptor binding, release of neuropeptides and variations in phosphatidylinositol turnover, which need further study.

Key words

Amitriptylineautonomic stimulationrat parotidsubmandibular saliva

Copyright information

© Rapid Communications of Oxford Ltd 1992

Authors and Affiliations

  • Jia-Huey Yu
    • 1
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical Center and Oral Pathology Research Laboratory, Department of Veterans Affairs Medical CenterWashington, DCUSA