Acta Neurochirurgica

, Volume 49, Issue 3, pp 207–217

Proteolytic enzyme activity in patients with severe head injury and the effect of a proteinase inhibitor

Authors

  • L. M. Auer
    • University Clinic of Neurosurgery
    • Institute of Medical Biochemistry
  • E. Marth
    • University Clinic of Neurosurgery
    • Institute of Medical Biochemistry
  • F. Heppner
    • University Clinic of Neurosurgery
    • Institute of Medical Biochemistry
  • A. Holasek
    • University Clinic of Neurosurgery
    • Institute of Medical Biochemistry
Article

DOI: 10.1007/BF01808960

Cite this article as:
Auer, L.M., Marth, E., Heppner, F. et al. Acta neurochir (1979) 49: 207. doi:10.1007/BF01808960

Summary

A study was performed to detect the inhibitory effect of intravenously administered aprotinin (Trasylol®) on brain and CSF protease activity in 25 patients with severe head injury. The data presented include measurements of CSF protease activity, alpha-1-antitrypsin, alpha-2-macroglobulin, haptoglobulin, polyacrylamidgel-electrophoresis pattern, total protein and hemoglobin content. The results indicate that increased protease activity is present and that this induces autolytic processes which can be inhibited by aprotinin treatment. The survival rate was higher after aprotinin treatment. Total CSF protein content was significantly higher in nonsurvivors than in survivors.

Keywords

CSF-proteasesHead injuryProtease inhibitor

Copyright information

© Springer-Verlag 1979