Breast Cancer Research and Treatment

, Volume 5, Issue 1, pp 3–10

Interobserver reproducibility of histopathological features in stage II breast cancer

An ECOG Study
  • Kennedy W. Gilchrist
  • Leslie Kalish
  • Victor E. Gould
  • Simon Hirschl
  • Joseph E. Imbriglia
  • Walter M. Levy
  • Arthur S. Patchefsky
  • Donald W. Penner
  • John Pickren
  • Joel A. Roth
  • Roger A. Schinella
  • Ira S. Schwartz
  • James E. Wheeler
Viewpoints

DOI: 10.1007/BF01807642

Cite this article as:
Gilchrist, K.W., Kalish, L., Gould, V.E. et al. Breast Cancer Res Tr (1985) 5: 3. doi:10.1007/BF01807642

Summary

Eleven surgical pathologists studied microscopic sections from 45 mastectomy specimens of node positive breast cancer patients who had been entered into ECOG clinical trials. Inter-observer reproducibility for histoprognostic features was examined as a prerequisite before a subsequent evaluation of their possible clinical applicability could be undertaken. Histological type, nuclear grade, tubular formation, and lymphoid reactions were studied in the cancerous tissues. Lymph nodal responses (follicular and pulp prominence, sinus histiocytosis) were also examined in a manner that simulated slide review in routine surgical pathology practice. Numerous two-way comparisons of the pathologists' findings resulted in low levels of agreement (usually ≪90%). The degree of inter-observer reliability is clinically unacceptable using customary slide review analysis. New ways of examining breast cancer tissues need to be explored in the search for prognostic features which can be applied to the clinical management of breast cancer patients.

Keywords

breast cancer histoprognosis interobserver nuclear grade reproducibility surgical pathology 

Copyright information

© Martinus Nijhoff Publishers 1985

Authors and Affiliations

  • Kennedy W. Gilchrist
    • 1
  • Leslie Kalish
    • 2
  • Victor E. Gould
    • 3
  • Simon Hirschl
    • 4
  • Joseph E. Imbriglia
    • 5
  • Walter M. Levy
    • 6
  • Arthur S. Patchefsky
    • 7
  • Donald W. Penner
    • 8
  • John Pickren
    • 9
  • Joel A. Roth
    • 10
  • Roger A. Schinella
    • 11
  • Ira S. Schwartz
    • 12
  • James E. Wheeler
    • 13
  1. 1.Wisconsin Clinical Sciences CenterMadisonUSA
  2. 2.Dana-Farber Cancer InstituteBostonUSA
  3. 3.Rush-Presbyterian-St. Luke's Medical CenterChicagoUSA
  4. 4.Our Lady of Lourdes HospitalBinghamtonUSA
  5. 5.N.P.W. Medical CenterWilkes-BarreUSA
  6. 6.American Oncologic HospitalPhiladelphiaUSA
  7. 7.Thomas Jefferson University HospitalPhiladelphiaUSA
  8. 8.Health Sciences CentreWinnipegUSA
  9. 9.Roswell Park Memorial InstituteBuffaloUSA
  10. 10.Overlook HospitalSummitUSA
  11. 11.Bellevue HospitalNew YorkUSA
  12. 12.Mount Sinai Medical CenterNew YorkUSA
  13. 13.Hospital of the University of PennsylvaniaPhiladelphiaUSA
  14. 14.ECOG Operations OfficeMedical Science CenterMadisonUSA

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