Breast Cancer Research and Treatment

, Volume 40, Issue 3, pp 265–270

Effects of tamoxifen on serum lipid and apolipoprotein levels in postmenopausal patients with breast cancer

  • Manuel Morales
  • Norberto Santana
  • Adela Soria
  • Alicia Mosquera
  • José Ordovás
  • Javier Nóvoa
  • Pedro Betancor
  • Pilar F. Valerón
  • Bonifacio Díaz-Chico
  • Ricardo Chirino
Report

DOI: 10.1007/BF01806815

Cite this article as:
Morales, M., Santana, N., Soria, A. et al. Breast Cancer Res Tr (1996) 40: 265. doi:10.1007/BF01806815

Abstract

Serum lipids and apolipoprotein levels were measured in twenty postmenopausal women with primary breast cancer, before and three months after tamoxifen therapy (10 mg twice a day). Tamoxifen caused a significant reduction in total serum cholesterol (10%;P < 0.02), and in low-density lipoprotein cholesterol (17%;P < 0.01), and a significant 47 % increase in the subclass 2 of the high density lipoprotein cholesterol (P< 0.01). In addition, tamoxifen caused a 16% increase in apolipoprotein A-I, a 12% decrease in apolipoprotein B (P < 0.05), and a 37% reduction in the serum concentration of lipoprotein(a) (P< 0.01). These results show that tamoxifen brings about an important improvement in serum lipid profile.

Key words

apolipoproteinsbreast cancercardiovascular diseaselipoproteinslipoprotein(a)tamoxifen

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Manuel Morales
    • 1
  • Norberto Santana
    • 2
  • Adela Soria
    • 3
  • Alicia Mosquera
    • 3
  • José Ordovás
    • 4
  • Javier Nóvoa
    • 5
  • Pedro Betancor
    • 5
  • Pilar F. Valerón
    • 2
  • Bonifacio Díaz-Chico
    • 2
  • Ricardo Chirino
    • 2
  1. 1.Division of Medical OncologyHospital Nuestra Señora de la CandelariaTenerifeSpain
  2. 2.Department of Cellular and Molecular EndocrinologyUniversity Las Palmas G.C.Spain
  3. 3.Department of Clinical ChemistryHospital InsularLas PalmasSpain
  4. 4.Lipid Metabolism LaboratoryUSDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA
  5. 5.Department of Clinical SciencesUniversity Las Palmas de G.C. Canary IslandsSpain
  6. 6.Dpto. Endocrinología C. & M., Centro de Ciencias de la SaludUniversidad de Las Palmas G.C.Las Palmas de Gran CanariaSpain