Breast Cancer Research and Treatment

, Volume 10, Issue 1, pp 5–9

Prognostic factors for recurrence and survival in human breast cancer

  • Wiliam L. McGuire
9th San Antonio Breast Cancer Symposium: Plenary lecture

DOI: 10.1007/BF01806129

Cite this article as:
McGuire, W.L. Breast Cancer Res Tr (1987) 10: 5. doi:10.1007/BF01806129


Since only about half of primary breast cancer patients are cured by local treatment, factors which can predict which patients are likely to recur and should thus receive preventive treatmrnt are needed. Here, work on such prognostic factors which has been going on in San Antonio for many years will be reviewed. The significance of the number of involved axillary nodes and of steroid receptors is already well known, while the value of tumor proliferative rate and ploidy has been appreciated more recently, and the significance of amplification of the oncogene HER-2/neu is just now emerging.

Key words

aneuploidy estrogen receptor flow cytometry HER-2/neu nodal status oncogene progesterone receptor prognosis proliferative rate S-phase 

Copyright information

© Martinus Nijhoff Publishers 1987

Authors and Affiliations

  • Wiliam L. McGuire
    • 1
  1. 1.Medicine/OncologyUniversity of Texas Health Science CenterSan AntonioUSA

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