Origins of life and evolution of the biosphere

, Volume 18, Issue 3, pp 281–287

The chemical logic of a minimum protocell

  • Harold J. Morowitz
  • Bettina Heinz
  • David W. Deamer
Article

DOI: 10.1007/BF01804674

Cite this article as:
Morowitz, H.J., Heinz, B. & Deamer, D.W. Origins Life Evol Biosphere (1988) 18: 281. doi:10.1007/BF01804674

Abstract

Traditional schemes for the origin of cellular life on earth generally suppose that the chance assembly of polymer synthesis systems was the initial event, followed by incorporation into a membrane-enclosed volume to form the earliest cells. Here we discuss an alternative system consisting of replicating membrane vesicles, which we define as minimum protocells. These consist of vesicular bilayer membranes that self-assemble from relatively rare organic amphiphiles present in the prebiotic environment. If some of the amphiphiles are primitive pigment molecules asymmetrically oriented in the bilayer, light energy can be captured in the form of electrochemical ion gradients. This energy could then be used to convert relatively common precursor molecules into membrane amphiphiles, thereby providing an initial photosynthetic growth process, as well as an appropriate microenvironment for incorporation and evolution of polymer synthesis systems.

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Harold J. Morowitz
    • 1
  • Bettina Heinz
    • 2
  • David W. Deamer
    • 3
  1. 1.Department of Molecular Biophysics and BiochemistryYale UniversityNew HavenUSA
  2. 2.Institute of Organic ChemistryJ.W. Goethe UniversityFrankfurt am MainF.R.G.
  3. 3.Department of ZoologyUniversity of CaliforniaDavisUSA