Journal of Inherited Metabolic Disease

, Volume 15, Issue 5, pp 707–712

Allopurinol challenge test in children

  • A. B. Burlina
  • V. Ferrari
  • C. Dionisi-Vici
  • A. Bordugo
  • F. Zacchello
  • M. Tuchman
Article

DOI: 10.1007/BF01800010

Cite this article as:
Burlina, A.B., Ferrari, V., Dionisi-Vici, C. et al. J Inherit Metab Dis (1992) 15: 707. doi:10.1007/BF01800010

Summary

The allopurinol challenge test was performed on 44 healthy subjects (28 children and 16 adolescents) in order to establish normal values of urinary orotic acid excretion following allopurinol ingestion in the paediatric population. The subjects were divided into three groups according to their age: 6 months to 6 years; 6 years to 10 years; and 10 years to 17 years. They were given 100 mg, 200 mg, or 300 mg of allopurinol, respectively (based on age) in a single oral dose. Maximum peak urinary orotic acid levels following ingestion of allopurinol were 13.0 (n=14), 9.3 (n=14), and 10.2 (n=16) µmol/mmol creatinine in the three groups, respectively. In all children tested the peak orotic acid level was 3.1±2.7 µmol/mmol creatinine (mean ± SD,n=44). This allopurinol challenge test was also performed in six children with ureacycle disorders, including five females with ornithine transcarbamylase (OTC) deficiency, all of whom demonstrated abnormally elevated levels of urinary orotic acid (peak levels of 26–134 µmol/mmol creatinine) following allopurinol ingestion.

Copyright information

© SSIEM and Kluwer Academic Publishers 1992

Authors and Affiliations

  • A. B. Burlina
    • 1
  • V. Ferrari
    • 1
  • C. Dionisi-Vici
    • 2
  • A. Bordugo
    • 1
  • F. Zacchello
    • 1
  • M. Tuchman
    • 3
  1. 1.Department of PediatricsUniversity of PaduaPaduaItaly
  2. 2.Department of MetabolismBambino Gesu Children's HospitalRomeItaly
  3. 3.Division of Genetics and Metaboilsm, Departments of Pediatrics and Laboratory Medicine and PathologyUniversity of MinnesotaMinneapolisUSA