Inflammation Research

, Volume 44, Issue 9, pp 372–375

Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema

  • L. H. Jones
  • D. S. P. Abdalla
  • J. C. Freitas
Original Research Papers

DOI: 10.1007/BF01797863

Cite this article as:
Jones, L.H., Abdalla, D.S.P. & Freitas, J.C. Inflamm Res (1995) 44: 372. doi:10.1007/BF01797863

Abstract

The indole-3-acetic acid (IAA) is a plant growth hormone (auxin) being considered as a tryptophan metabolite in animals. The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents. IAA antioxidant activity was also verified by measuring the inhibition of brain homogenate lipid peroxidation with the thiobarbituric acid reactive substances (TBARS) test. IAA inhibited the action of both croton oil- and arachidonic acid-induced edema in a dose-dependent manner (4.0 µmoles IAA inhibited 75.8% in croton oil and 82.5% in arachidonic acid induced ear edema). Both IAA (5.3 mM) and indomethacin (8.0 mM) inhibited TBARS formation. Data suggest that IAA exhibits antiinflammatory effect possibly by its antioxidant activity.

Keywords

Indole-3-acetic acidMouse ear edemaAntioxidantsCroton oilArachidonic acid

Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • L. H. Jones
    • 1
  • D. S. P. Abdalla
    • 2
  • J. C. Freitas
    • 1
  1. 1.Department of Physiology, Biosciences InstituteUniversity of São Paulo, Rua do MatãoSão PauloBrazil
  2. 2.Department of Clinical and Toxicological Analyses, Pharmaceutical Sciences FacultyUniversity of São PauloBrazil